Spontaneous regression is partial or complete reduction of a malignant tumor without treatment or in the presence of therapy that is considered inadequate to exert a significant influence on neoplastic disease. We report herein a patient with lung cancer who had a spontaneous regression of scalp metastasis with no treatment performed. This is the first report of the spontaneous regression of scalp metastasis of lung cancer. The patient should be carefully followed up to chart his unusual clinical course.