Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

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• 作者：Naoya Matsunaga^a ; ^b ; ¹ ; Eriko Ikeda^c ; ¹ ; Keisuke Kakimoto^a ; ¹ ; Miyako Watanabe^a ; ¹ ; Naoya Shindo^d ; ¹ ; Akito Tsuruta^a ; ¹ ; Hisako Ikeyama^a ; ¹ ; Kengo Hamamura^c ; ¹ ; Kazuhiro Higashi^a ; Tomohiro Yamashita^e ; Hideaki Kondo^f ; Yuya Yoshida^a ; Masaki Matsuda^a ; Takashi Ogino^a ; Kazutaka Tokushige^a ; Kazufumi Itcho^a ; Yoko Furuichi^a ; Takaharu Nakao^a ; Kaori Yasuda^g ; Atsushi Doi^g ; Toshiaki Amamoto^h ; Hironori Aramaki^c ; Makoto Tsudaⁱ ; Kazuhide Inoue^e ; Akio Ojida^d ; ¹ ; Satoru Koyanagi^a ; ^b ; Shigehiro Ohdo^a ; ¹ ; ^{ohdo@phar.kyushu-u.ac.jp}
• 关键词：Chronic renal disease ; Circadian clock ; G0s2 ; Small compound inhibitor
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：262-273
• 全文大小：2037 K
• 卷排序：13

文摘

Chronic renal inflammation in CKD was ameliorated by clock mutation. G0s2 was important for the anti-inflammatory effects of clock mutation. A novel small-molecule inhibitor of G0s2 ameliorated renal inflammation in CKD.Matsunaga et al. found that G0/G1 switch 2 (G0s2) was important for renal inflammation and that a novel small-molecule inhibitor of G0s2 ameliorated renal dysfunction in chronic renal disease (CKD). G0s2 enhanced p65-mediated transcription. Moreover, renal inflammation was regulated by G0s2/Stat5 through the molecular clock mechanism. Finally, G0s2 knockdown or inhibition ameliorated renal dysfunction in CKD.