Bisubstrate-type inhibitor of sialyltransferases

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• 作者：Hinou ; Hiroshi ; Sun ; Xue-Long ; Ito ; Yukishige
• 关键词：sialyltransferase ; inhibitor ; bisubstrate
• 刊名：Tetrahedron Letters
• 出版年：2002
• 出版时间：December 9, 2002
• 年：2002
• 卷：43
• 期：50
• 页码：9147-9150
• 全文大小：141 K

文摘

A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory activities toward both 2,3-(N)- and 2,6-(N)-sialyltransferase.