Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
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- 作者：Yoku Hayakawa1 ; 12 ; Hiroshi Ariyama1 ; 12 ; Jitka Stancikova2 ; Kosuke Sakitani1 ; Samuel Asfaha1 ; Bernhard W. Renz1 ; 11 ; Zinaida A. Dubeykovskaya1 ; Wataru Shibata1 ; Hongshan Wang1 ; Christoph B. Westphalen1 ; Xiaowei Chen1 ; Yoshihiro Takemoto1 ; Woosook Kim1 ; Shradha S. Khurana1 ; Yagnesh Tailor1 ; Karan Nagar1 ; Hiroyuki Tomita3 ; Akira Hara3 ; Antonia R. Sepulveda4 ; Wanda Setlik5 ; Michael D. Gershon5 ; Subhrajit Saha6 ; Lei Ding7 ; Zeli Shen8 ; James G. Fox8 ; Richard A. Friedman9 ; Stephen F. Konieczny10 ; Daniel L. Worthley1 ; Vladimir Korinek2 ; Timothy C. Wang1 ; tcw21@columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2015
- 出版时间：14 December 2015
- 年：2015
- 卷：28
- 期：6
- 页码：800-814
- 全文大小：7892 K
文摘
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Quiescent Mist1+ stem cells reside in the corpus isthmus
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Mist1+ stem cells are a cellular origin of gastric cancers
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Cxcl12/Cxcr4 perivascular niche supports isthmus stem cells
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Wnt5a from Cxcr4+ ILCs promotes diffuse cancer development