Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy
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- 作者：Motoi Kanagawa1 ; 7 ; Kazuhiro Kobayashi1 ; 7 ; Michiko Tajiri2 ; 7 ; Hiroshi Manya3 ; 7 ; Atsushi Kuga1 ; 7 ; Yoshiki Yamaguchi4 ; Keiko Akasaka-Manya3 ; Jun-ichi Furukawa5 ; Mamoru Mizuno6 ; Hiroko Kawakami6 ; Yasuro Shinohara5 ; Yoshinao Wada2 ; 8 ; waday@lab.mch.pref.osaka.jp" class="auth_mail" title="E-mail the corresponding author ; Tamao Endo3 ; 8 ; endo@tmig.or.jp" class="auth_mail" title="E-mail the corresponding author ; Tatsushi Toda1 ; 8 ; toda@med.kobe-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：14
- 期：9
- 页码：2209-2223
- 全文大小：4761 K
文摘
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Ribitol 5-phosphate is a functional glycan unit in mammals
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α-dystroglycan function requires tandem ribitol 5-phosphate structure
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Muscular dystrophy proteins are involved in ribitol 5-phosphate glycosylation
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Supplementation with ribitol 5-phosphate metabolites may be a therapeutic strategy