Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

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• 作者：Maryam Zaid ; MSc^a ; ^{mzaid@belle.shiga-med.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Katsuyuki Miura ; MD ; PhD^a ; ^b ; Akira Fujiyoshi ; MD ; PhD^a ; Robert D. Abbott ; PhD^b ; Takashi Hisamatsu ; MD ; PhD^a ; ^b ; Aya Kadota ; MD ; PhD^a ; ^b ; Hisatomi Arima ; MD ; PhD^a ; ^b ; Sayaka Kadowaki ; MD ; PhD^a ; Sayuki Torii ; MD ; PhD^a ; Naoko Miyagawa ; PhD ; RD^a ; Sentaro Suzuki ; MD^a ; Naoyuki Takashima ; MD ; PhD^a ; Takayoshi Ohkubo ; MD ; PhD^c ; Akira Sekikawa ; MD ; PhD ; PhD^d ; Hiroshi Maegawa ; MD ; PhD^e ; Minoru Horie ; MD ; PhD^f ; Yasuyuki Nakamura ; MD ; PhD^a ; ^g ; Tomonori Okamura ; MD ; PhD^h ; Hirotsugu Ueshima ; MD ; PhD^a ; ^b ; for the SESSA Research GroupHirotsugu Ueshima (Chairperson) ; Katsuyuki Miura (Co-chairperson) ; Minoru Horie ; Yasutaka Nakano ; Takashi Yamamoto ; Emiko Ogawa ; Hiroshi Maegawa ; Itsuko Miyazawa ; Kiyoshi Murata ; Kenichi Mitsunami ; Kazuhiko Nozaki ; Akihiko Shiino ; Isao Araki ; Teruhiko Tsuru ; Ikuo Toyama ; Hisakazu Ogita ; Souichi Kurita ; Toshinaga Maeda ; Naomi Miyamatsu ; Toru Kita ; Takeshi Kimura ; Yoshihiko Nishio ; Yasuyuki Nakamura ; Tomonori Okamura ; Akira Sekikawa ; Emma J.M. Barinas-Mitchell ; Daniel Edmundowicz ; Takayoshi Ohkubo ; Atsushi Hozawa ; Nagako Okuda ; Aya Higashiyama ; Shinya Nagasawa ; Yoshikuni Kita ; Yoshitaka Murakami ; Aya Kadota ; Akira Fujiyoshi ; Naoyuki Takashima ; Takashi Kadowaki ; Sayaka Kadowaki ; Robert D. Abbott ; Seiko Ohno ; Hisatomi Arima ; Takashi Hisamatsu ; Naoko Miyagawa ; Sayuki Torii ; Yoshino Saito ; Maryam Zaid ; Sentaro Suzuki ; Takahiro Ito
• 关键词：Low-density lipoprotein particle (LDL-P) ; Low-density lipoprotein cholesterol (LDL-C) ; Carotid intima-media thickness (cIMT) ; Coronary artery calcification (CAC) ; Subclinical atherosclerosis
• 刊名：Journal of Clinical Lipidology
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：10
• 期：5
• 页码：1195-1202.e1
• 全文大小：182 K

文摘

Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).

Objectives

Whether LDL-P is associated with subclinical atherosclerosis, independent of LDL-C, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.

Methods

We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40–79 years from 2006–2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; >0 Agatston score) were examined.

Results

LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.

Conclusions

In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P.