- 作者：Shinya Kawase ; MD&lowast ; ; charley.sk@med.tottori-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hisanori Kowa ; MD ; PhD&lowast ; ; Yutaka Suto ; MD ; PhD&dagger ; ; Hiroki Fukuda ; MD ; PhD&Dagger ; ; Masayoshi Kusumi ; MD ; PhD§ ; ; Hiroyuki Nakayasu ; MD ; PhD&dagger ; ; Kenji Nakashima ; MD ; PhD&lowast ;
- 关键词：modified Rankin Scale ; brain damage ; neurohumoral change ; renin-angiotensin aldosterone system ; sympathetic nervous system
- 刊名：Journal of Stroke and Cerebrovascular Diseases
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：24
- 期：10
- 页码：2285-2290
- 全文大小：159 K
Method
This study analyzed consecutive Japanese patients with acute ischemic stroke. Correlations between plasma BNP level and conventional risk factors for ischemic stroke were examined. Values of P less than .05 were considered statistically significant.
Results
This study analyzed 718 acute ischemic stroke patients (445 men and 273 women; mean age, 73.9 years). Mean plasma level of BNP was significantly higher for CEI (366.6 pg/ml) than for non-CEI (105.6 pg/ml; P < .01). Poor outcome (modified Rankin Scale score ≥3) at hospitalization and discharge were associated with significantly higher plasma BNP level than good outcome (modified Rankin Scale score ≤2) for both CEI and non-CEI. On multiple regression analysis, log-BNP was significantly associated with female sex, smoking, triglyceride, and creatinine clearance in CEI. In non-CEI, log-BNP was significantly associated with systolic/diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol, and creatinine clearance.
Conclusion
Irrespective of the presence of CEI, plasma BNP offers a marker of prognostic functional outcome. We clarified the characteristics and differences associated with plasma BNP in CEI and non-CEI, and our results suggest that plasma BNP can provide a useful marker of brain damage and neurohumoral dynamics in acute ischemic stroke.