- 作者：Emiko Noguchi ; Rina Kato ; Kayoko Ohno ; Atsushi Mitsui ; Takashi Obama ; Tsutomu Hirano ; Hiroyuki Itabe ; Matsuo Yamamoto
- 关键词：apoB ; apolipoprotein B ; BMI ; body mass index ; BOP ; bleeding on probing ; CM ; chylomicron ; DM ; diabetes mellitus ; ELISA ; enzyme-linked immunosorbent assay ; GA ; glycoalbumin ; GCF ; gingival crevicular fluid ; HbA1c ; hemoglobin A1c ; HDL-C ; high-density lipoprotein cholesterol ; LDL-C ; low-density lipoprotein cholesterol ; mAb ; monoclonal antibody ; MDA-LDL ; malondialdehyde-modified low-density lipoprotein ; NGSP ; National Glycohemoglobin Standardization Program ; oxLDL ; oxidized low-density lipoprotein ; pA
- 刊名：Clinical Biochemistry
- 出版年：January, 2014
- 年：2014
- 卷：47
- 期：1-2
- 页码：67-71
- 全文大小：296 K
Objective
Oral health conditions have a significant relationship with diabetes mellitus (DM) as well as dyslipidemia. In this study, we investigated the levels of apolipoprotein B (apoB) and oxidized low-density lipoprotein (oxLDL) in the gingival crevicular fluid (GCF) from patients with DM.Methods
GCF and blood samples from 18 DM patients and 18 healthy subjects were examined. GCF was collected with paper points without inflicting any harm. The apoB and oxLDL levels were measured by sandwich ELISA assays.
Results
The number of teeth with a deep probing pocket depth and the number of teeth with bleeding on probing, two typical periodontal parameters, correlated with the DM parameters, such as hemoglobin A1c. The GCF volume and the concentrations of protein, apoB and oxLDL in GCF were significantly higher in the DM patients than in the healthy subjects. In particular, the apoB concentration in GCF was increased 6-fold in the DM patients. The GCF apoB concentration correlated well with the DM parameters in plasma.
Conclusion
GCF could be a clinical source for examining not only the oral status of patients, but also certain systemic conditions.