Highly sensitive quantification of unconjugated 11-nor-9-carboxy-Δ<sup>9sup>-tetrahydrocannabinol in a cannabis user's hair using micropulverized extraction
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- 作者：Kenji Kuwayama<sup> ; sup><sup>kuwayama@nrips.go.jp" class="auth_mail" title="E-mail the corresponding authorsup> ; Hajime Miyaguchi ; Tadashi Yamamuro ; Kenji Tsujikawa ; Tatsuyuki Kanamori ; Yuko T. Iwata ; Hiroyuki Inoue
- 关键词：Hair ; THC-COOH ; Glucuronide ; Micropulverized extraction ; LC/MS
- 刊名：Forensic Science International
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：262
- 期：Complete
- 页码：e34-e36
- 全文大小：332 K
文摘
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We previously developed a quantitative method of THC-COOH using spiked hair.
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In this study, the method proved to be applicable to cannabis user's hair.
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In addition, we found that 26% of THC-COOH in hair occurs in the conjugated form.
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MPE enabled to quantify unconjugated THC-COOH, unlike alkaline dissolution of hair.
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MPE would be used to discriminate between unconjugated and conjugated form in hair.