H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation
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- 作者：Yoshihiro Matsumura1 ; 4 ; matsumura-y@lsbm.org" class="auth_mail" title="E-mail the corresponding author ; Ryo Nakaki2 ; Takeshi Inagaki1 ; 4 ; Ayano Yoshida1 ; 5 ; Yuka Kano1 ; Hiroshi Kimura6 ; Toshiya Tanaka1 ; 3 ; 4 ; Shuichi Tsutsumi2 ; Mitsuyoshi Nakao7 ; Takefumi Doi8 ; Kiyoko Fukami5 ; Timothy F. Osborne9 ; Tatsuhiko Kodama3 ; Hiroyuki Aburatani2 ; 4 ; Juro Sakai1 ; 4 ; jmsakai-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Histone methylation ; DNA methylation ; bivalent chromatin domains ; epigenome ; adipogenesis ; lineage commitment ; gene-body methylation ; H3K4me3 ; H3K9me3 ; H3K27me3 ; RNA polymerase II
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：19 November 2015
- 年：2015
- 卷：60
- 期：4
- 页码：584-596
- 全文大小：2887 K
文摘
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H3K4/H3K9me3 bivalent domains exist in mesenchymal stem cells and preadipocytes
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SETDB1 contributes to the formation of the H3K4/H3K9me3 bivalent domains
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Lineage-specific gene-body DNA methylation recruits SETDB1 repressive complex
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H3K4/H3K9me3 bivalent domains inhibit Cebpa and Pparg expression and adipogenesis