Intracranial Plaque Characterization in Patients with Acute Ischemic Stroke Using Pre- and Post-Contrast Three-Dimensional Magnetic Resonance Vessel Wall Imaging

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• 作者：Tatsunori Natori ; MD ; PhD^* ; ^{tnatori@iwate-med.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Makoto Sasaki ; MD^&dagger ; ; Mitsuharu Miyoshi ; MSc^&Dagger ; ; Kohei Ito ; MD^* ; Hideki Ohba ; MD ; PhD^* ; Haruna Miyazawa ; MD^* ; Shinsuke Narumi ; MD ; PhD^* ; Hiroyuki Kabasawa ; PhD^&Dagger ; ; Taisuke Harada ; MD^&dagger ; ; Yasuo Terayama ; MD ; PhD^*
• 关键词：Vessel wall imaging ; MRI ; stroke ; atherosclerosis
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：25
• 期：6
• 页码：1425-1430
• 全文大小：375 K

文摘

Magnetic resonance vessel wall imaging (VWI) techniques have been developed to assess atherosclerotic plaques in intracranial arteries, which are a cardinal cause of ischemic stroke. However, the clinical roles of plaque-related vulnerability and inflammation remain unclear. Hence, we evaluated plaque characteristics using VWI of the proximal middle cerebral artery (M1) in patients with acute ischemic stroke.

Methods

We prospectively examined 30 consecutive patients with acute noncardioembolic stroke in the M1 territory using pre-/postcontrast T1-weighted (T1W) three-dimensional (3D) VWI with a 3-Tesla scanner. The contrast ratio (CR) and contrast enhancement of the plaques were measured bilaterally at M1.

Results

Plaques were identified in the bilateral M1s of all patients, and no substantial stenosis existed. The M1 plaque CRs ipsilateral to the infarct (46.7%-67.9%) were significantly higher than the plaque CRs on the contralateral side (34.3%-69.4%), particularly in patients with lacunar infarcts (P < .01). In contrast, the occurrence of plaque enhancement was not different between the ipsilateral (20.0%) and contralateral (16.7%) sides. Further, the CRs in the nonlacunar group were significantly higher than the CRs in the lacunar group (P < .05), whereas enhanced plaques tended to be more frequent in the nonlacunar group, but this difference was not significant (P = .09).

Conclusions

T1W 3D-VWI revealed that the signal intensity of M1 plaques was significantly higher in the affected side and in nonlacunar-type infarcts of patients with acute stroke, suggesting that unstable plaques in the M1 can cause stroke events presumably due to atherothrombotic mechanisms.