Aging differentially alters the expression of angiogenic genes in a tissue-dependent manner
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- 作者：Yoshiaki Shimoda ; Kiyonari Matsuo ; Kazunori Ono ; Yuka Soma ; Tomomi Ueyama ; Satoaki Matoba ; Hiroyuki Yamada ; Koji Ikeda ; ikedak@koto.kpu-m.ac.jp" class="auth_mail
- 关键词：Aging ; Angiogenesis ; Age-related disease ; Metabolic disorder ; White adipose tissue
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：18 April 2014
- 年：2014
- 卷：446
- 期：4
- 页码：1243-1249
- 全文大小：1111 K
文摘
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Aging differentially alters the expression of angiogenic genes in different tissues.
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Angiogenic genes were mostly down-regulated in white adipose tissue of aged mice.
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Vascularity was reduced and hypoxia was exacerbated in WAT of aged mice.
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ER stress is involved in the age-related changes of angiogenic gene expression.