Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity
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- 作者：Yuki Tachida ; Koji Suda ; Hiroyuki Nagase ; Kohei Shimada ; Fujio Isono ; Hideki Kobayashi ; kobayashi.hideki.gc@daiichisankyo.co.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mesenchymal stem cells ; Conditioned medium ; Cardioprotection ; Furin/PCSK5
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：7
- 期：Complete
- 页码：266-272
- 全文大小：1076 K
文摘
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ASC-CM protects against OGD-induced cell death of adult cardiomyocytes.
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Furin/PCSK enzyme activity is protective against OGD-induced cell death.
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PCSK5A is the main component of cardioprotective activity of ASC-CM.