The immunogenetics of primary biliary cirrhosis: A comprehensive review
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- 作者：G.J. Webba ; ; K.A. Siminovitchb ; G.M. Hirschfielda ; g.hirschfield@bham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Genome-wide association study ; Immunochip ; HLA ; CD4+ T cell ; Animal models ; Regulatory T cell
- 刊名：Journal of Autoimmunity
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：64
- 期：Complete
- 页码：42-52
- 全文大小：2045 K
文摘
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Primary biliary cirrhosis is a typical autoimmune disease with a strong genetic component.
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Genome-wide studies have greatly expanded understanding of genetic risk.
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This review highlights individual associations including HLA types and the IL-12-STAT4 pathway.
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Animal models, epigenetics and novel immunological therapies are also considered.