Spectroscopic, single crystal X-ray, Hirshfeld, in vitro and in silico biological evaluation of a new series of potent thiazole nucleus integrated with pyrazoline scaffolds
文摘
A new series of 1,3-thiazole integrated pyrazoline scaffolds are synthesized and characterized. The reduced radical scavenging activity of compounds could be attributed to sterically hindered conformation. The compounds bound effectively to antibacterial target pyrimdine nucleoside hydrolase YbeK with bound ribose complex.