Empty follicle syndrome in the setting of dramatic weight loss after bariatric surgery: case report and review of available literature

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• 作者：Jennifer Hirshfeld-Cytron ; Helen H. Kim
• 关键词：Empty follicle syndrome ; gastric bypass ; bariatric surgery ; weight-reduction surgery ; skin redundancy ; assisted reproduction ; infertility ; drug absorption
• 刊名：Fertility and Sterility
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：90
• 期：4
• 页码：1199.e21-1199.e23
• 全文大小：79 K

文摘

Objective

To describe empty follicle syndrome, potentially due to route of human chorionic gonadotropin (hCG) administration, in a patient who had previously undergone bariatric surgery.

Design

Case report and review of literature.

Setting

Academic medical center.

Patient(s)

A 42-year-old nulliparous, morbidly obese woman who had presented for assisted reproduction treatment after having lost 175 pounds via gastric bypass surgery, resulting in abdominal skin redundancy.

Intervention(s)

The patient's gastric bypass surgery had resulted in abdominal skin redundancy. In her first cycle, recombinant hCG was used with a luteal gonadotropin-releasing hormone (GnRH) agonist/recombinant follicle-stimulation hormone (FSH) protocol. At hCG administration, her estradiol level was 2342 pg/mL, and 18 follicles were measured. At retrieval, no oocytes were recovered, and her serum hCG level was 19 mIU/mL. In the subsequent cycle, identical ovarian stimulation was performed, with peak estradiol of 2891 pg/mL, but intramuscular hCG was administered. At retrieval, her serum hCG level was 45 mIU/mL, and 19 oocytes were recovered, resulting in 10 embryos. Five embryos were transferred, and a singleton pregnancy resulted.

Main Outcome Measure(s)

Recovery of oocytes.

Result(s)

Clinical pregnancy.

Conclusion(s)

Abdominal skin redundancy after bariatric surgery may alter the absorption of subcutaneously administered infertility medications. Additional studies are needed to treat infertile patients optimally after weight-reduction surgery.