Increased risk of humerus and lower leg fractures in postmenopausal women with self-reported premenopausal hirsutism and/or oligomenorrhea

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• 作者：Fabio V. Comim^a ; ^{fabio.comim@ufsm.br" class="auth_mail" title="E-mail the corresponding author} ; Luana Q. Marchesan^a ; Rafaela M. Copes^a ; Adhan R. de Vieira^a ; Rafael N. Moresco^b ; Juliet E. Compston^c ; Melissa O. Premaor^a
• 关键词：Hyperandrogenism ; Bone fracture ; Hirsutism ; Oligomenorrhea
• 刊名：European Journal of Obstetrics & Gynecology and Reproductive Biology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：203
• 期：Complete
• 页码：162-166
• 全文大小：282 K

文摘

The aim of this study was to investigate the prevalence of fracture in women aged >55 years with self-reported premenopausal hirsutism and/or oligomenorrhea.

Study design

A cross-sectional study including 1057 post-menopausal women aged >55 years who were treated in a primary care facility in Santa Maria, South Brazil, from March 2013 through August 2013. Data were collected using a standardized questionnaire for characteristics including fracture history, medication use, and reproductive history (oligomenorrhea, hirsutism, miscarriage, the diagnosis or treatment of hypothyroidism, hyperprolactinemia, or infertility).

Results

A non-significant trend towards an increased prevalence of all fragility fractures was observed in women with premenopausal hirsutism and/or oligomenorrhea when compared to those without (20.4% vs. 15.7%). After correction for age, falls, and comorbidities, fracture prevalence was significantly higher in the lower leg (OR 3.1 [CI 1.1–8.6]; P = 0.029), and humerus (OR 2.6 [CI 1.2–5.4]; P = 0.015) in the women with hirsutism and/or oligomenorrhea.

Conclusion

This is a hypothesis-generating study which evaluated the association between hirsutism and/or oligomenorrhea and fractures in postmenopausal women. Our results suggest that premenopausal hirsutism and/or oligomenorrhea may be associated with an increased risk of fracture postmenopause, particularly in the humerus and lower leg.