Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
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- 作者：Bassem Sadeka ; bassem.sadek@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author ; Ali Saada ; Adel Sadeqb ; Fakhreya Jalala ; Holger Starkc
- 关键词：AD ; Alzheimer&rsquo ; s disease ; ADHD ; attention-deficit hyperactivity disorder ; AED ; antiepileptic drugs ; Akt ; also known as protein kinase B ; cAMP ; cyclic adenosine mono-phosphate ; CREB ; cAMP response element-binding ; α-FMH ; α-fluromethylhistidine ; GPCR ; G-protein coupled receptor ; GSK3β ; glycogen synthase kinase 3β ; H1R ; histamine H1 receptor ; H2R ; histamine H2 receptor ; H3R ; histamine H3 receptor ; H4R ; histamine H4 receptor ; HDC ; histidine decarboxylase ; KO ; knockout ; LAAT ; l-amino acid transp
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：312
- 期：Complete
- 页码：415-430
- 全文大小：3892 K
文摘
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H1-4R sub-types are described.
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Pharmacological profiles of cherry-picked H3R ligands are provided.
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A variety of animal models investigating H3R ligands are offered.
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Emphasis is given on cognitive symptoms in neuropsychiatric diseases.