The magnificent two: histamine and the H3 receptor as key modulators of striatal circuitry

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• 作者：Maximiliano Rapanelli ^{maximiliano.rapanelli@yale.edu}
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2017
• 出版时间：6 February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：36-40
• 全文大小：450 K
• 卷排序：73

文摘

Brain region specific signaling of H3R Activation of H3R in the striatum is Gi independent. Striatal H3R triggers MAPK activation in D1-MSNs and AKT/GSK3β in D2-MSNs. Aberrant histaminergic function is a potential cause of tic disorders. H3R as a target for treating neuropsychiatric disorders and addictions