Neoplastic cellularity is associated with clinical and molecular features of high-grade serous ovarian carcinoma
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- 作者：Christopher B. Morsea ; cbmorse@uw.edu" class="auth_mail" title="E-mail the corresponding author ; Barbara M. Norquista ; Maria I. Harrella ; Kathy J. Agnewa ; Heidi J. Graya ; Renata R. Urbana ; Rochelle L. Garciab ; Barbara A. Goffa ; Elizabeth M. Swishera
- 关键词：Ovarian cancer ; BRCA1 ; BRCA2 ; Cancer histology
- 刊名：Gynecologic Oncology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：143
- 期：2
- 页码：389-392
- 全文大小：560 K
文摘
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One-third of high-grade serous ovarian, peritoneal and fallopian tube carcinomas (HGSC) have low percentage of neoplastic nuclei (PNN < 70%).
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Higher PNN is associated with suboptimal cytoreduction and lower PNN is associated with inherited BRCA2 mutations.
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Molecular analyses of HGSC selected for high PNN exclude a significant fraction of patients.