Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes

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• 作者：Shinsuke Ishigaki¹ ; ² ; ¹² ; ^{ishigaki-ns@umin.net} ; Yusuke Fujioka¹ ; ¹² ; Yohei Okada³ ; Yuichi Riku¹ ; ⁴ ; Tsuyoshi Udagawa¹ ; Daiyu Honda¹ ; Satoshi Yokoi¹ ; Kuniyuki Endo¹ ; Kensuke Ikenaka¹ ; Shinnosuke Takagi¹ ; Yohei Iguchi¹ ; Naruhiko Sahara⁵ ; Akihiko Takashima⁶ ; Hideyuki Okano⁷ ; Mari Yoshida⁴ ; Hitoshi Warita⁸ ; Masashi Aoki⁸ ; Hirohisa Watanabe¹ ; ⁹ ; Haruo Okado¹⁰ ; Masahisa Katsuno¹ ; Gen Sobue¹ ; ⁹ ; ¹¹ ; ¹³ ; ^{sobueg@med.nagoya-u.ac.jp}
• 关键词：FTLD ; FUS ; tau ; SFPQ ; adult neurogenesis
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1118-1131
• 全文大小：3985 K
• 卷排序：18

文摘

The nuclear interaction between FUS and SFPQ is affected by disease mutations FUS/SFPQ regulate tau isoforms by altering skipping of Mapt exon 10 Silencing of FUS or SFPQ in adult mice induces FTLD-like phenotypes Co-silencing of 4R-T rescues the FTLD-like phenotypes in FUS/SFPQ-silenced mice