Small differences in structure, a large difference in activity - Comparing a new Ru(II)-3-hydroxyiminoflavanone complex with analogous Ru(II) compounds

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• 作者：M. Kasprzak^a ; ^{maria.kasprzak@umed.lodz.pl} ; M. Fabijańska^a ; L. Chęcińska^b ; K. Studzian^c ; M. Markowicz-Piasecka^d ; J. Sikora^d ; E. Mikiciuk-Olasik^e ; J. Ochocki^a
• 关键词：1 ; 3-hydroxyiminoflavanone ; 2 ; cis-dichlorido(3-nitrosoflavone)(3-hydroxyiminoflavanone)-ruthenium(II) ; 3 ; cis-dichloridobis(3-imino-2-methoxyflavanone)ruthenium(II) ; 4 ; cis-dichloridobis(3-imino-2-ethoxyflavanone)ruthenium(II) ; APTT ; activated partial thromboplastin time ; Cisplatin ; cis-diaminedichloridoplatinum(II) ; CLAUC ; overall potential of the clot formation and lysis ; CL-test ; coagulation test ; DMF ; N&prime ; N&prime ; -dimethylformamide ; DMSO ; dimethylsulfoxide ; ESI ; Electronic Supplementar
• 刊名：Inorganica Chimica Acta
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：457
• 期：Complete
• 页码：69-80
• 全文大小：1449 K
• 卷排序：457

文摘

A new complex of ruthenium(II) with 3-hydroxyiminoflavanone was obtained. The complex formation is accompanied with redox reaction between ligand and Ru ion. Cytotoxicity of the complex is surprisingly low, compared to two similar ones. The reason is probably the higher stability and lower lipophilicity of new complex. None of the three complexes significantly alters the hemostasis process.