Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia

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• 作者：Steven H. Graham ; M.D. Ph.D.^a ; ^b ; ^{Steven.Graham@va.gov} ; Hao Liu^a ; ^b
• 关键词：Ubiquitin ; Ubiquitin proteasome pathway (UPP) ; Neurodegenerative disease ; Ubiquitin carboxy-terminal hydrolase L1(UCHL1) ; Cerebral ischemia ; Aging
• 刊名：Ageing Research Reviews
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：30-38
• 全文大小：1610 K
• 卷排序：34

文摘

The UPP is essential for removing abnormal proteins from the neuron. UPP dysfunction occurs in normal aging and neurodegenerative diseases. UPP disruption by ischemia may contribute to the risk of neurodegenerative diseases. UCHL1 is inhibited after ischemia resulting in UPP dysfunction. Restoring UCHL1 activity is a novel therapeutic approach for these disorders.