N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding
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- 作者：Katherine I. Zhou1 ; Marc Parisien2 ; Qing Dai3 ; Nian Liu3 ; Luda Diatchenko2 ; Joseph R. Sachleben4 ; Tao Pan5 ; 6 ; taopan@uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MALAT1 ; metastasis associated lung adenocarcinoma transcript 1 ; HNRNPC ; heterogeneous nuclear ribonucleoprotein C ; FRET ; Fö ; rster resonance energy transfer ; NOESY ; nuclear Overhauser enhancement spectroscopy ; NOE ; nuclear Overhauser enhancement
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：27 February 2016
- 年：2016
- 卷：428
- 期：5
- 页码：822-833
- 全文大小：1093 K
文摘
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m6A alters the conformation of the HNRNPC binding site in a MALAT1 hairpin.
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m6A modification biases the MALAT1 hairpin toward its protein-bound conformation.
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m6A can influence many cellular functions by influencing protein binding.