Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression
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- 作者：Yu Wua ; b ; c ; e ; 1 ; Yuying Fub ; c ; 1 ; Chenglong Raoa ; b ; c ; 1 ; Wenwen Lib ; c ; f ; 1 ; Zihong Liangb ; c ; g ; Chanjuan Zhoub ; c ; Peng Shenb ; c ; d ; Pengfei Chengb ; c ; Li Zengb ; c ; Dan Zhub ; d ; Libo Zhaoa ; b ; Peng Xieb ; c ; d ; xiepeng58@21cn.com" class="auth_mail" title="E-mail the corresponding author ; xiepeng@cqmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BW ; body weight ; CNS ; central nervous system ; CUMS ; chronic unpredictable mild stress ; DLPFC ; dorsolateral prefrontal cortex ; FST ; forced swimming test ; GABA ; γ-aminobutyric acid ; GC&ndash ; MS ; gas chromatography&ndash ; mass spectrometry ; HMDB ; human metabolome tatabase ; IPA ; ingenuity pathways analysis ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; LC&ndash ; MS ; liquid chromatography&ndash ; mass spectrometry ; LPS ; lipopolysaccharide ; MDD ; major depressive disorder ; NMR ; nuclear magnetic resonance
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：115-127
- 全文大小：3414 K
文摘
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Successfully constructed the LPS-induced mouse model of depression.
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GC–MS-based metabolic profiling was conducted.
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A total of 20 differential metabolites were identified.
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Differentially expressed metabolites are mainly involved in amino acid, lipid, energy, and oxidative stress metabolism.