Implications of genotypic differences in the generation of a urinary metabolomics radiation signature
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- 作者：Evagelia C. Laiakisa ; ecl28@georgetown.edu" class="auth_mail" title="E-mail the corresponding author ; Evan L. Pannkuka ; Maria Elena Diaz-Rubiob ; Yi-Wen Wanga ; Tytus D. Makc ; Cynthia M. Simbulan-Rosenthala ; David J. Brennerd ; Albert J. Fornace Jra ; e ; f
- 关键词：IR ; ionizing radiation ; LC ; liquid chromatography ; MS ; mass spectrometry ; TCA ; tricarboxylic acid ; WT ; wild type ; CT ; computed tomography ; PARP1 ; poly(ADP-ribose)polymerase 1 ; BER ; base excision repair ; SIRT1 ; sirtuin-1 ; D1 ; day 1 ; D3 ; day 3 ; HMDB ; the Human Metabolome Database ; KEGG ; Kyoto encyclopedia of genes and genomes ; QC ; quality control ; FDR ; false discovery rate ; SEM ; standard error of the mean ; ANOVA ; one-way analysis of variance ; ROC ; receiver characteristic curves ; FMN ; flavin mononu
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：788
- 期：Complete
- 页码：41-49
- 全文大小：1975 K
文摘
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Metabolomics can rapidly assess the collective small molecule content in biofluids.
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Previous studies focused on urine of wild type mice and now extending to radiosensitive mice.
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The Parp1−/− mice were utilized as a model radiosensitive mouse line.
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Time-dependent perturbations are evident in different metabolic pathways.
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Metabolomics can be used to dissect the effects of genotoxic agents on metabolism.