Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo
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- 作者：Lin Lia ; Huanmin Niub ; Bin Suna ; Yanan Xiaoc ; Wei Lia ; Huiqing Yuanb ; Hongxiang Loua ; louhongxiang@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：RD-N ; Riccardin D-N ; LMP ; lysosomal membrane permeabilization ; ASM ; acid sphingomyelinase ; SM ; sphingomyelin ; CADs ; cationic amphiphilic drugs ; LAMP1 ; lysosome associated membrane protein 1 ; PARP ; poly (ADP-ribose) polymerase ; LDH ; lactate dehydrogenase ; PCD ; programmed cell death ; HMU-PC ; 6-hexadecanoylamino-4-methylumbelliferylphosphorylcholine ; IHC ; immunohistochemistry ; CTSB ; cathepsin B ; CTSD ; cathepsin D ; CTSL ; cathepsin L
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：175-184
- 全文大小：2042 K
文摘
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Riccardin D-N (RD-N) significantly downregulated LAMP1 expressions.
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RD-N inhibited the acid sphingomyelinase activity.
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RD-N induced lysosomal membrane permeabilization in vivo.
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RD-N induced SM accumulation in the lysosomal membranes.
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RD-N also induced the release of cathepsins from destabilized lysosomes.