Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma
详细信息 查看全文
- 作者：Ioanna Vallianoua ; Dimitra Dafoua ; Niki Vassilakib ; Penelope Mavromarab ; Margarita Hadzopoulou-Cladarasa ; cladaras@bio.auth.gr" class="auth_mail" title="E-mail the corresponding author (Professor of Developmental Biology)
- 关键词：AP ; acute phase ; APR ; acute phase response ; C3 ; complement component 3 ; DEN ; diethylnitrosamine ; FBG-β ; fibrinogen beta ; HCC ; hepatocellular carcinoma ; HCV ; hepatitis C virus ; HNF1α ; hepatocyte nuclear factor 1 alpha ; HNF4α ; hepatocyte nuclear factor 4 alpha ; HP ; haptoglobin ; h.p.t. ; hours post transfection ; IL6R ; interleukin 6 receptor ; MTP ; microsomal triglyceride transfer protein ; NS ; non-structural ; SAA-1 ; serum amyloid A1 ; pSTAT3 ; phosphorylated STAT3 ; STAT3 ; transducer and activator of tra
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：315-326
- 全文大小：2246 K
文摘
-
HCV suppresses HNF4α expression in both RNA and protein levels.
-
HCV viral proteins reduce HNF4α expression.
-
HCV viral proteins downregulate HNF4α promoter activity.
-
HCV perturbs HNF4α-related microRNA (miR-24, miR-629 and miR-124) expression.