Primary afferent-evoked synaptic plasticity in deep dorsal horn neurons from neonatal rat spinal cord in vitro

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• 作者：Garraway ; Sandra M. ; Pockett ; Susan ; Hochman ; Shawn
• 关键词：Long-term potentiation ; Long-term depression ; Nociception ; Development
• 刊名：Neuroscience Letters
• 出版年：1997
• 出版时间：July 11, 1997
• 年：1997
• 卷：230
• 期：1
• 页码：61-64
• 全文大小：333 K

文摘

Whole-cell patch clamp recordings of deep dorsal horn neurons were undertaken in ‘thick' transverse slices to demonstrate plasticity of primary afferent-evoked synaptic responses following conditioning stimulation. Synaptic plasticity was observed in neurons throughout the age range examined (postnatal days 3–6 and 9–16) but only long-term depression (LTD) was evocable in older animals (P9–16). Both short- and long-latency synaptic responses could undergo long-term potentiation (LTP) and LTD suggesting that AMPA/kainate and NMDA receptor-evoked responses are modifiable.