Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro

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• 作者：Hochman ; Shawn ; Garraway ; Sandra M. ; Pockett ; Susan
• 关键词：Spinal cord ; Development ; Slice
• 刊名：Brain Research
• 出版年：1997
• 出版时间：September 5, 1997
• 年：1997
• 卷：767
• 期：2
• 页码：214-219
• 全文大小：523 K

文摘

Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3–6 and 9–16. In both age groups, significant correlations were observed between membrane time constant and cell resistance and between action potential height and its duration at half-maximal amplitude. Cell resistance and action potential half-width values were lower in the P9–16 age group. Neurons were divided into four categories based on their firing properties in response to intracellular current injection: single spike, phasic firing, repetitive firing, and delayed firing. The distribution of neurons within these categories was similar in both age groups which suggests that the firing properties of deep dorsal horn neurons are functionally differentiated at an early postnatal age.