Antimicrobial activity against Streptococcus pneumoniae and Haemophilus influenzae collected globally between 2004 and 2008 as part of the Tigecycline Evaluation and Surveillance Trial

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• 作者：Ali Darabi ; Didier Hocquet ; Michael J. Dowzicky
• 关键词：Streptococcus pneumoniae ; Haemophilus influenzae ; Tigecycline ; Antimicrobial surveillance ; Resistance
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：67
• 期：1
• 页码：78-86
• 全文大小：200 K

文摘

We report here on the in vitro activity of tigecycline and comparators against a global collection of Streptococcus pneumoniae and Haemophilus influenzae collected between 2004 and 2008 as part of the Tigecycline Evaluation and Surveillance Trial. A total of 6785 S. pneumoniae and 6642 H. influenzae isolates were collected, most from North America. The percentages of penicillin-intermediate resistance and penicillin resistance among S. pneumoniae in North America were 27.8 % and 14.3 % , respectively. Penicillin resistance ranged from 9.3 % in Europe to 25.1 % in the Asia-Pacific Rim. The rate of β-lactamase–producing H. influenzae was 25.8 % in North America, and among the other regions, it ranged from 8.7 % in South Africa to 26.8 % in the Asia-Pacific Rim. Tigecycline MIC₉₀'s were 0.03 to 0.12 mg/L and 0.5 to 2 mg/L, depending on the region considered, against S. pneumoniae and H. influenzae, respectively. Tigecycline had low MIC₉₀'s against S. pneumoniae and H. influenzae, irrespective of resistance to β-lactams.