Novel splice variants of CXCR4 identified by transcriptome sequencing
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- 作者：L.G.L. Sanda ; A.G. Jochemsenb ; E. Beletkaiac ; T. Schmidtc ; P.C.W. Hogendoorna ; K. Szuhaib ; k.szuhai@lumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：CXCR4 ; Splicing ; Next generation sequencing ; Ewing sarcoma ; Bone tumors ; Soft tissue tumor
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：9 October 2015
- 年：2015
- 卷：466
- 期：1
- 页码：89-94
- 全文大小：876 K
文摘
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Two novel CXCR4 splice variants were discovered using whole transcriptome sequencing.
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Novel splice variants were expressed in cell lines, tumor samples and placenta.
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Validation at protein level demonstrated dominantly unstable proteins.
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CXCR4-3 demonstrates an effect in HEK293T cell line at functional level.