CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients
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- 作者：L.G.L. Sanda ; K. Scotlandib ; D. Berghuisc ; B.E. Snaar-Jagalskad ; P. Piccib ; T. Schmidte ; K. Szuhaif ; P.C.W. Hogendoorna ; P.C.W.Hogendoorn@lumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Splice variant ; Tumour microenvironment ; Biomarker ; Molecular targeted therapy
- 刊名：European Journal of Cancer
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：51
- 期：17
- 页码：2624-2633
- 全文大小：670 K
文摘
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CXCR7, CXCR4, CXCL12, CXCL14 and CXCR4 isoforms are expressed in Ewing sarcoma.
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CXCR4-1/CXCR4-2 isoform ratio and CXCL14 and CXCR7 associate with improved survival.
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CXCR4 and CXCL12 mRNA expression are not associated with survival in Ewing sarcoma.
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Factors mitigating CXCR4 activation predict better clinical outcomes.