- 作者：W.M. Admiraal ; F. Holleman ; M.B. Snijder ; R.J.G. Peters ; L.M. Brewster ; J.B.L. Hoekstra ; K. Stronks ; I.G.M. van Valkengoed
- 关键词：Ethnicity ; IFG ; Type 2 diabetes incidence
- 刊名：Diabetes Research and Clinical Practice
- 出版年：January, 2014
- 年：2014
- 卷：103
- 期：1
- 页码：127-132
- 全文大小：537 K
Aims
Evidence of ethnic disparities in the conversion of prediabetes to type 2 diabetes is scarce. We studied the association of impaired fasting glucose (IFG) and fasting plasma glucose (FPG) with the 10-year cumulative incidence of type 2 diabetes in three ethnic groups.Methods
We analyzed data for 90 South-Asian Surinamese, 190 African-Surinamese, and 176 ethnic Dutch that were collected in the periods 2001-2003 and 2011-2012. We excluded those with type 2 diabetes or missing FPG data. We defined baseline IFG as FPG of 5.7-6.9 mmol/L. We defined type 2 diabetes at follow-up as FPG 鈮?#xA0;7.0 mmol/L, HbA1c 鈮?#xA0;48 mmol/mol (6.5%), or self-reported type 2 diabetes.
Results
10-Year cumulative incidences of type 2 diabetes were: South-Asian Surinamese, 18.9%; African-Surinamese, 13.7%; ethnic Dutch, 4.5% (p < 0.05). The adjusted association of baseline IFG and FPG with the 10-year cumulative incidence of type 2 diabetes was stronger for South-Asian Surinamese than for African-Surinamese and ethnic Dutch. The IFG (compared to normoglycaemia) ORs were 11.1 [3.0-40.8] for South-Asian Surinamese, 5.1 [2.0-13.3] for African-Surinamese, and 2.2 [0.5-10.1] for ethnic Dutch.
Conclusions
The 10-year cumulative incidence of type 2 diabetes was higher and associations with baseline IFG and FPG were stronger among South-Asian Surinamese and African-Surinamese than among ethnic Dutch. Our findings confirm the high risk of type 2 diabetes in South-Asians and suggest more rapid conversion in populations of South-Asian origin and (to a lesser extent) African origin than European origin.