Comp Plan: A computer program to generate dose and radiobiological metrics from dose-volume histogram files

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• 作者：Lois Charlotte Holloway ; Ph.D.^? ; ^&dagger ; ; ^&Dagger ; ; ^{lois.holloway@sswahs.nsw.gov.au} ; Julie-Anne Miller ; M.Sc.^? ; ^&Dagger ; ; Shivani Kumar ; B.Sc.^? ; Brendan M. Whelan ; B.Sc.^&Dagger ; ; Shalini K. Vinod ; M.D.^? ; ^§ ;
• 关键词：DVH ; Radiobiology ; Software ; Program
• 刊名：Medical Dosimetry
• 出版年：2012
• 出版时间：Autumn, 2012
• 年：2012
• 卷：37
• 期：3
• 页码：305-309
• 全文大小：746 K

文摘

Treatment planning studies often require the calculation of a large number of dose and radiobiological metrics. To streamline these calculations, a computer program called Comp Plan was developed using MATLAB. Comp Plan calculates common metrics, including equivalent uniform dose, tumor control probability, and normal tissue complication probability from dose-volume histogram data. The dose and radiobiological metrics can be calculated for the original data or for an adjusted fraction size using the linear quadratic model. A homogeneous boost dose can be added to a given structure if desired. The final output is written to an Excel file in a format convenient for further statistical analysis. Comp Plan was verified by independent calculations. A lung treatment planning study comparing 45 plans for 7 structures using up to 6 metrics for each structure was successfully analyzed within approximately 5 minutes with Comp Plan. The code is freely available from the authors on request.