Cloning, expression, molecular characterization and preliminary studies on immunomodulating properties of recombinant Trypanosoma congolense calreticulin

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• 作者：Geraldine Bossard^a ; ^{geraldine.bossard@cirad.fr} ; Pascal Gré ; baut^b ; ^{pascal.grebaut@ird.fr} ; Sophie Thé ; venon^a ; ^{sophie.thevenon@cirad.fr} ; Martial Sé ; veno^c ; ^{martial.seveno@fpp.cnrs.fr} ; David Berthier^a ; ^{david.berthier@cirad.fr} ; Philippe Holzmuller^d ; ^{philippe.holzmuller@cirad.fr}
• 关键词：Animal African Trypanosomosis ; Calreticulin ; Trypanosoma congolense ; Antibodies ; Immunomodulation
• 刊名：Infection, Genetics and Evolution
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：45
• 期：Complete
• 页码：320-331
• 全文大小：3194 K
• 卷排序：45

文摘

calreticulin (CRT) has shown differential expression between two T. congolense strains with opposite infectious behavior we produced and performed molecular charactrization of one recombinant T. congolense calreticulin we set out to determine the role of T. congolense calreticulin as an immunomodulating target immunization of mice with recombinant T. congolense calreticulin induced specific antibody production. anti-CRT antibody production was associated with delayed parasitemia and increased survival of the challenged animal