SALL4, the missing link between stem cells, development and cancer
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- 作者：Hiro Tatetsua ; 1 ; Nikki R. Konga ; 1 ; Gao Chonga ; Giovanni Amabileb ; Daniel G. Tenenc ; d ; Li Chaia ; lchai@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：ESCs ; embryonic stem cells ; SALL ; Spalt-like ; C2H2 ; Cys(2)his(2) ; Q ; glutamine ; ZF ; zinc finger ; AAs ; amino acids ; ICM ; inner cell mass ; HSPCs ; hematopoietic stem/progenitor cells ; PND7 ; postnatal day 7 ; HCC ; hepatocellular carcinoma ; CDX1 ; caudal-related homeobox 1 ; iPS ; induced pluripotent stem ; MEF ; mouse embryonic fibroblast ; OSK ; Oct4 ; Sox2 ; and Klf4 ; OSKM ; Oct4 ; Sox2 ; Klf4 ; and Myc ; SNEL ; Sall4 ; Nanog ; Esrrb ; and Lin28 ; NuRD ; Nucleosome remodelling and histone deacetylase ; DRRS ; Okihiro/Du
- 刊名：Gene
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：584
- 期：2
- 页码：111-119
- 全文大小：1272 K
文摘
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This review summarizes the gene structure, expression and function(s) of SALL4.
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SALL4 plays an essential role in embryonic stem cells.
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Mutations in the SALL4 gene cause Okihiro/Duane-radial ray syndrome.
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SALL4 is de-regulated and aberrantly expressed in various cancers.
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SALL4 can be a cancer-specific target.