Oxidative stress by H2O2 or angiotensin II increased HERPUD1 mRNA and protein levels in HeLa cells.
HERPUD1 knockdown in HeLa cells increased cytosolic Ca2+ levels upon H2O2 stimulation.
HERPUD1 knockdown in HeLa cells increased inositol trisphosphate receptor protein levels.
HERPUD1 knockdown increase HeLa apoptosis through a Ca2+-dependent mechanism.