Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages
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- 作者：Fenglei Chena ; b ; Pengfei Lina ; b ; Nan Wanga ; b ; Diqi Yanga ; b ; Xin Wena ; b ; Dong Zhoua ; b ; Aihua Wangb ; Yaping Jina ; b ; yapingjin@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atg ; autophagy-related proteins ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; ERAD ; ER-associated protein degradation ; FBS ; fetal bovine serum ; Fisher LSD ; Fisher's least significant different test ; GS ; glucose starvation ; Herp ; homocysteine-responsive ER-resident protein ; LC3 ; microtubule-associated protein 1 light chain 3 ; LPS ; lipopolysaccharide ; MTT ; 3-[4 ; 5-dimethylthiazol-2-yl]-2 ; 5-diphenyltetrazolium bromide assay ; poly-Ub ; poly-ubiquitin
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：115-122
- 全文大小：1645 K
文摘
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ZEA up-regulated ER stress-related proteins Herp expression and autophagy-related protein LC3-I conversion to LC3-II in dose- and time-dependent manners.
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Herp depletion up-regulated LC3-I conversion to LC3-II treated with ZEA.
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Herp depletion had a protective role in ZEA-induced cell death via up-regulating autophage.