Osteoprotegerin levels are associated with liver fat and liver markers in dysmetabolic adults

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• 作者：M. Monseu^a ; ^{mathilde.monseu@ens-lyon.org" class="auth_mail" title="E-mail the corresponding author} ; S. Dubois^b ; ^{sedubois@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author} ; J. Boursier^c ; ^{jeboursier@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author} ; C. Aubé ; ^d ; ^{chaube@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author} ; F. Gagnadoux^e ; ^{frgagnadoux@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author} ; G. Lefthé ; riotis^f ; ^{geleftheriotis@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author} ; P.-H. Ducluzeau^g ; ^{ph.ducluzeau@chu-tours.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Insulin resistance ; Liver steatosis ; Metabolic syndrome ; Osteoprotegerin ; Vascular complications
• 刊名：Diabetes & Metabolism
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：42
• 期：5
• 页码：364-367
• 全文大小：395 K

文摘

This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults.

Methods

Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. They then underwent a thorough metabolic and cardiovascular evaluation, including arterial stiffness, atherosclerotic plaques, homoeostasis model assessment for insulin resistance (HOMA-IR) indices and OPG. VAT and LF content were measured by magnetic resonance imaging (MRI). Ultrasound examination of arteries and arterial stiffness were recorded, and age- and gender-adjusted paired correlations calculated.

Results

Body mass index, waist circumference and MRI-derived VAT correlated with OPG, whereas abdominal subcutaneous fat did not. OPG levels were strongly correlated with LF content (r = 0.25, P = 0.003), liver markers such as alanine aminotransferase (r = 0.39, P < 0.001) and HOMA-IR index (r = 0.39, P < 0.0001). Plasma OPG also correlated with arterial stiffness and the number of atherosclerotic sites.

Conclusion

Plasma OPG levels are positively associated with both liver markers and increased LF content, but not with subcutaneous fat in dysmetabolic men. These findings suggest that elevated OPG levels may play a role in the link between fatty liver disease and enhanced cardiovascular risk.