Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus

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• 作者：Ning Li ; Jia-Yu Zhang ; Ke-Wu Zeng ; Liang Zhang ; Yan-Yun Che ; Peng-Fei Tu
• 关键词：Ophiopogon japonicus ; Homoisoflavonoids ; Anti-inflammatory ; Inhibitory effects of nitric oxide production ; Ophiopogonone E ; Ophiopogonanone H
• 刊名：Fitoterapia
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：83
• 期：6
• 页码：1042-1045
• 全文大小：434 K

文摘

Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC₅₀ values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 ¦ÌM respectively.