A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase

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• 作者：Huanjie Guo^a ; ^b ; Huanxin Zhao^a ; Yuichiro Kanno^c ; Wei Li^c ; ^{liwei@phar.toho-u.ac.jp} ; Yanling Mu^a ; Xinzhu Kuang^c ; Yoshio Inouye^c ; Kazuo Koike^c ; Haipeng Jiang^d ; Hong Bai^a ; ^{baihong@gmail.com}
• 关键词：Polygonatum odoratum ; Homoisoflavonoids ; Dihydrochalcone ; AMPK activation
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：1 June, 2013
• 年：2013
• 卷：23
• 期：11
• 页码：3137-3139
• 全文大小：339 K

文摘

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis; thus, AMPK plays a central role in studies on diabetes and related metabolic diseases. From the rhizomes of Polygonatum odoratum (Mill.) Druce, six homoisoflavonoids (1-6) and one dihydrochalcone (7) were isolated, and the structures of polygonatones A-D (4-7) were elucidated by various spectroscopic analyses. Compounds 1-7 were evaluated for their effect on AMPK activation. The amount of active phosphorylated AMPK and acetyl-CoA carboxylase in rat liver epithelial IAR-20 cells increased when the cells were incubated with the aforementioned compounds. Specifically, (3R)-5,7-dihydroxyl-6-methyl-8-methoxyl-3-(4¡ä-hydroxylbenzyl)-chroman-4-one (1), (3R)-5,7-dihydroxyl-6,8-dimethyl-3-(4¡ä-hydroxylbenzyl)-chroman-4-one (2), (3R)-5,7-dihydroxyl-6-methyl-3-(4¡ä-hydroxylbenzyl)-chroman-4-one (3), and polygonatone D (7) exhibited significant activation effects.