The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots

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• 作者：Yu-Chi Tsai^a ; Shang-Yu Chiang^a ; Mohamed El-Shazly^a ; ^b ; Chin-Chung Wu^a ; Ludger Beerhues^c ; Wan-Chun Lai^a ; Shou-Fang Wu^a ; Ming-Hong Yen^a ; Yang-Chang Wu^d ; ^e ; ^f ; ^{yachwu@mail.cmu.edu.tw} ; Fang-Rong Chang^a ; ^g ; ^h ; ^{aaronfrc@kmu.edu.tw}
• 关键词：Liriope platyphylla ; Dihydrobenzofuroisocoumarin ; Homoisoflavonoid ; Oestrogenic activity ; Anti-platelet effect ; Arabidopsis pER8 ; GUS reporter assay
• 刊名：Food Chemistry
• 出版年：2013
• 出版时间：1-15 September, 2013
• 年：2013
• 卷：140
• 期：1-2
• 页码：305-314
• 全文大小：877 K

文摘

The ethanolic extract of Liriope platyphylla (Liliaceae) roots showed potential oestrogenic and anti-platelet activities. Twenty-six compounds were isolated and classified as 10 skeletons, including two unusual new dihydrobenzofuroisocoumarins, (+)-platyphyllarin A (1) and B (2), one new butanoate, ethyltributanoate (3), and two new homoisoflavanones, (?)-liriopein A (4) and B (5), along with 21 known compounds, including six homoisoflavonoids, one chalcone, six amides, one lignan, one fatty acid derivative, one alkaloid, three benzenoids, and two steroids. The biosynthetic pathway of compounds 1 and 2 was proposed in the current investigation. The oestrogenic activity of the isolates was evaluated utilising the pER8:GUS reporter assay system in transgenic Arabidopsis plant as well as the SEAP reporter assay system in MCF-7 breast cancer cell-line; the anti-platelet activity was evaluated using the anti-platelet aggregation assay. Several components exhibited significant oestrogenic and anti-platelet activities; demonstrating for the first time the potential use of L. platyphylla as a nutritional supplement for cardiovascular and endocrine diseases.