Investigation of JAK1 and STAT3 polymorphisms and their gene-gene interactions in nonspecific digestive disorder of rabbits
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- 作者：Lu Fu fushaolu@163.com" class="auth_mail ; Zhi-Juan Yang ; Shi-Yi Chen ; Jie Wang ; Song-Jia Lai ; laisj5794@gmail.com" class="auth_mail
- 关键词：JAK1 ; Janus kinase 1 ; STAT3 ; signal transducer and activator of transcription 3 ; cSNPs ; coding single nucleotide polymorphisms ; SH2 ; Src homology-2 domains ; NSDD ; nonspecific digestive disorder ; IBD ; inflammatory bowel disease ; CD ; Crohn's disease ; UC ; ulcerative colitis ; HRM ; high-resolution melting technology ; ORs ; Odds ratios ; CIs ; confidence intervals ; RSCU ; relative synonymous codon usage ; MDR ; multifactor dimensionality reduction method
- 刊名：Gene
- 出版年：10 June 2014
- 年：2014
- 卷：543
- 期：1
- 页码：8-14
- 全文大小：325 K
文摘
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To explore genetic resistance, this experiment based on a case–control study.
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Genotyping by a combination of both RFLP and HRM.
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Five inheritance models were to evaluate the importance of associated genotypes.
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The MDR method was used to analyze the genetic interactions.
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JAK1 and STAT3 play crucial roles in the susceptibility of rabbits to NSDD.