Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action
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- 作者：P. Maciejaka ; b ; piomac@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; J. Szyndlerb ; D. Turzyńskaa ; A. Sobolewskaa ; K. Kołosowskab ; P. Krząścikb ; A. Płaźnika ; b
- 关键词：5-HIAA ; 5-hydroxyindole acetic acid ; 5-HT ; serotonin ; AAA ; aromatic amino acids ; AAT ; aspartate aminotransferase ; ADT ; large neutral amino acid mixture ; ALA ; alanine ; ASP ; aspartate ; BBB ; blood&ndash ; brain barrier ; BCAA ; branched-chain amino acids ; BHM ; β-hydroxybutyric acid ; C10 ; decanoic acid ; C8 ; octanoic acid ; DA ; dopamine ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; FAs ; fatty acids ; GLTM ; glutamine ; GLU ; glutamate ; GLY ; glycine ; HVA ; homovanillic acid ; ILEU ; l-isoleucine ; KYN ; kynurenine ; KYNA
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：313
- 期：Complete
- 页码：130-148
- 全文大小：785 K
文摘
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Fatty acids increased the brain levels of tryptophan and kynurenic acid (KYNA).
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The antiseizure action of octanoic fatty acid may be related to changes in tryptophan metabolism.
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The octanoic fatty acid is crucial for antiseizure activity of medium-chain triglyceride ketogenic diet.