Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters
详细信息 查看全文
- 作者：Sumit Jamwala ; b ; Puneet Kumara ; punnubansal79@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-NP ; 3-Nitropropionic acid ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; 5-HIAA ; 5-Hydroxy-3-Indole acetic acid ; HVA ; Homovanillic Acid ; HD ; Huntington's disease ; IL-6 ; Interleukin-6 ; IL-1β ; Interleukin-1 ; < ; ; beta ; > ; ; MSNs ; Medium spiny neurons ; NMDA ; N-methyl-d-aspartate ; NMDAR ; N-methyl-d-aspartate receptor ; ROS ; Reactive oxygen species ; SDH ; Succinate dehydrogenase ; TNF-α ; Tumor necrosis factor-alpha
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：155
- 期：Complete
- 页码：180-187
- 全文大小：1242 K
文摘
- •
3-NP is well established experimental model of Huntington's disease.
- •
3-NP administration impaired motor coordination and induces striatal toxicity.
- •
Spermidine is a polyamine having NMDA receptor modulation property.
- •
Spermidine prevented alteration in neurotransmitters level and neuroinflammation.
- •
Antioxidant and anti-inflammatory effects contribute to effects of spermidine.