Association of the −1031 T > C polymorphism and soluble TNF-α levels with Acute Coronary Syndrome
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- 作者：Elena Sandoval-Pintoa ; b ; Jorge Ramó ; n Padilla-Gutié ; rreza ; Emmanuel Valdé ; s-Alvaradoa ; b ; Ilian Janet Garcí ; a-Gonzá ; leza ; c ; Angé ; lica Valdez-Haroa ; c ; José ; Francisco Muñ ; oz-Vallea ; Hector Enrique Flores-Salinasd ; Lorena Michele Brennan-Bourdona ; Yeminia Vallea ; yemivalle@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute Coronary Syndrome ; Genetic polymorphisms ; Proinflammatory cytokines ; Soluble protein ; TNF-α
- 刊名：Cytokine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：37-43
- 全文大小：522 K
文摘
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The polymorphic variant −1031 C of TNFA gene confers ACS protection.
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T/C+C/C ACS carriers had 2.31 times greater chance of developing dyslipidemia.
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Soluble TNF-α levels were higher in ACS than the RG.
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T/C carriers showed higher sTNF-α levels compared with T/T homozygotes in ACS.
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Serum TNF-α concentration was similar among UA, NSTEMI and STEMI.