Interaction between COMT Val158Met polymorphism and childhood adversity affects reward processing in adulthood
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- 作者：Regina Boecker-Schliera ; Nathalie E. Holza ; Arlette F. Buchmanna ; Dorothea Blomeyera ; Michael M. Plichtaa ; Christine Jennen-Steinmetzb ; Isabella Wolfa ; c ; Sarah Baumeistera ; Jens Treutleind ; Marcella Rietscheld ; Andreas Meyer-Lindenberge ; Tobias Banaschewskia ; Daniel Brandeisa ; f ; g ; h ; i ; ; Manfred Lauchta ; j ; 1 ; manfred.laucht@zi-mannheim.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Reward processing ; COMT Val158Met polymorphism ; Childhood adversity ; Gene&ndash ; environment interaction ; Functional magnetic resonance imaging ; Electroencephalography
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：556-570
- 全文大小：1760 K
文摘
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Interaction between COMT and childhood adversity on reward processing was examined.
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fMRI activity of Met homozygotes increased with adversity at reward delivery.
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fMRI activity decreased with childhood adversity during reward anticipation.
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Anticipatory EEG activity decreases with adversity provided converging evidence.