A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila

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• 作者：Jennifer Beshel¹ ; ⁴ ; ^{beshel@cshl.edu} ; Josh Dubnau¹ ; ² ; Yi Zhong¹ ; ³
• 关键词：obesity ; weight regulation ; food intake ; conserved circuits
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：208-217
• 全文大小：3207 K
• 卷排序：25

文摘

Fly upd1::npf and mammalian leptin::NPY circuits are functionally conserved Manipulating upd1 in the brain, not fat tissue, produces flies with obesity hallmarks Upd1 regulates state-dependent signaling in npf neurons though domeless receptors Circuit manipulations create hypersensitivity to obesogenic conditions