Isoflurane neurotoxicity involves activation of hypoxia inducible factor-1α via intracellular calcium in neonatal rodents
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- 作者：Dongdong Chai 15130576782@163.com" class="auth_mail" title="E-mail the corresponding author ; Hong Jiang 1241921060@qq.com" class="auth_mail" title="E-mail the corresponding author ; Qifang Li ; liqifang2004@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Isoflurane ; Hypoxia inducible factor-1α ; Neurotoxicity ; Calcium
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：1653
- 期：Complete
- 页码：39-50
- 全文大小：1457 K
文摘
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Isoflurane stimulates HIF-1α-mediated neurotoxicity.
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Ca2+ signaling pathways activation are required for isoflurane-evoked HIF-1α accumulation.
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PLC-ϒ plays an important role in isoflurane-induced increase in [Ca2+]c in primary hippocampal neurons.
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Partial deficiency of HIF-1α attenuated isoflurane-induced apoptosis in P7 developing brain
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Partial deficiency of HIF-1α partially ameliorated isoflurane-induced learning and memory impairment